Frontiers in Immunology (Nov 2021)
Pathogenesis of IgA Vasculitis: An Up-To-Date Review
- Yan Song,
- Yan Song,
- Yan Song,
- Yan Song,
- Yan Song,
- Xiaohan Huang,
- Xiaohan Huang,
- Xiaohan Huang,
- Xiaohan Huang,
- Xiaohan Huang,
- Guizhen Yu,
- Guizhen Yu,
- Guizhen Yu,
- Guizhen Yu,
- Guizhen Yu,
- Jianjun Qiao,
- Jun Cheng,
- Jun Cheng,
- Jun Cheng,
- Jun Cheng,
- Jun Cheng,
- Jianyong Wu,
- Jianyong Wu,
- Jianyong Wu,
- Jianyong Wu,
- Jianyong Wu,
- Jianghua Chen,
- Jianghua Chen,
- Jianghua Chen,
- Jianghua Chen,
- Jianghua Chen
Affiliations
- Yan Song
- Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Yan Song
- Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China
- Yan Song
- National Key Clinical Department of Kidney Diseases, Hangzhou, China
- Yan Song
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Yan Song
- The Third Grade Laboratory Under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China
- Xiaohan Huang
- Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Xiaohan Huang
- Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China
- Xiaohan Huang
- National Key Clinical Department of Kidney Diseases, Hangzhou, China
- Xiaohan Huang
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Xiaohan Huang
- The Third Grade Laboratory Under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China
- Guizhen Yu
- Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Guizhen Yu
- Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China
- Guizhen Yu
- National Key Clinical Department of Kidney Diseases, Hangzhou, China
- Guizhen Yu
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Guizhen Yu
- The Third Grade Laboratory Under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China
- Jianjun Qiao
- Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Jun Cheng
- Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Jun Cheng
- Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China
- Jun Cheng
- National Key Clinical Department of Kidney Diseases, Hangzhou, China
- Jun Cheng
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Jun Cheng
- The Third Grade Laboratory Under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China
- Jianyong Wu
- Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Jianyong Wu
- Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China
- Jianyong Wu
- National Key Clinical Department of Kidney Diseases, Hangzhou, China
- Jianyong Wu
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Jianyong Wu
- The Third Grade Laboratory Under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China
- Jianghua Chen
- Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
- Jianghua Chen
- Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China
- Jianghua Chen
- National Key Clinical Department of Kidney Diseases, Hangzhou, China
- Jianghua Chen
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Jianghua Chen
- The Third Grade Laboratory Under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China
- DOI
- https://doi.org/10.3389/fimmu.2021.771619
- Journal volume & issue
-
Vol. 12
Abstract
Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura (HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at diseased vessel walls. IgAV is the most common form of vasculitis in children; typical symptoms include palpable purpura, arthritis or arthralgia, abdominal pain, and hematuria or proteinuria. Galactose-deficient IgA1 is detected in the tissues of the kidney and skin in patients with IgAV; it forms immune complexes leading to subsequent immune reactions and injuries. This report provides the recent advances in the understanding of environmental factors, genetics, abnormal innate and acquired immunity, and the role of galactose-deficient IgA1 immunocomplexes in the pathogenesis of IgAV.
Keywords
