Hippocampal astrocytes modulate anxiety-like behavior

Woo-Hyun Cho; Kyungchul Noh; Byung Hun Lee; Ellane Barcelon; Sang Beom Jun; Hye Yoon Park; Sung Joong Lee

doi:10.1038/s41467-022-34201-z

Nature Communications (Nov 2022)

Hippocampal astrocytes modulate anxiety-like behavior

Woo-Hyun Cho,
Kyungchul Noh,
Byung Hun Lee,
Ellane Barcelon,
Sang Beom Jun,
Hye Yoon Park,
Sung Joong Lee

Affiliations

Woo-Hyun Cho: Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry
Kyungchul Noh: Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry
Byung Hun Lee: Department of Physics and Astronomy, Seoul National University
Ellane Barcelon: Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry
Sang Beom Jun: Department of Electronic and Electrical Engineering, Ewha Womans University
Hye Yoon Park: Department of Physics and Astronomy, Seoul National University
Sung Joong Lee: Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry

DOI: https://doi.org/10.1038/s41467-022-34201-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Astrocytes affect animal behaviors by regulating the tripartite synapse. Here, the authors show that hippocampal astrocytes modulate mouse anxiety-like behavior by regulating synaptic homeostasis of dentate gyrus granule cells via ATP release.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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