Communications Biology (Dec 2022)
CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations
- Hristina R. Zhekova,
- Jiansen Jiang,
- Weiguang Wang,
- Kirill Tsirulnikov,
- Gülru Kayık,
- Hanif Muhammad Khan,
- Rustam Azimov,
- Natalia Abuladze,
- Liyo Kao,
- Debbie Newman,
- Sergei Yu. Noskov,
- D. Peter Tieleman,
- Z. Hong Zhou,
- Alexander Pushkin,
- Ira Kurtz
Affiliations
- Hristina R. Zhekova
- Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary
- Jiansen Jiang
- Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
- Weiguang Wang
- Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
- Kirill Tsirulnikov
- Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
- Gülru Kayık
- Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary
- Hanif Muhammad Khan
- Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary
- Rustam Azimov
- Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
- Natalia Abuladze
- Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
- Liyo Kao
- Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
- Debbie Newman
- Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
- Sergei Yu. Noskov
- Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary
- D. Peter Tieleman
- Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary
- Z. Hong Zhou
- Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
- Alexander Pushkin
- Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
- Ira Kurtz
- Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
- DOI
- https://doi.org/10.1038/s42003-022-04306-8
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
CryoEM structures and computational modeling of bovine anion exchanger 1 in both inward and outward facing conformations reveal an elevator-like mechanism of ion transport by a solute carrier ion transport family 4 member.
