The conundrum of using hyperoxia in COVID-19 treatment strategies: may intermittent therapeutic hyperoxia play a helpful role in the expression of the surface receptors ACE2 and Furin in lung tissue via triggering of HIF-1α?

• Andreas Koch,
• Wataru Kähler,
• Sebastian Klapa,
• Bente Grams,
• Pieter- Jan A. M. van Ooij

Affiliations

Andreas Koch

Joint Section of Maritime Medicine, Naval Institute of Maritime Medicine and Christian-Albrechts-University Kiel

Wataru Kähler

Joint Section of Maritime Medicine, Naval Institute of Maritime Medicine and Christian-Albrechts-University Kiel

Sebastian Klapa

Joint Section of Maritime Medicine, Naval Institute of Maritime Medicine and Christian-Albrechts-University Kiel

Bente Grams

Joint Section of Maritime Medicine, Naval Institute of Maritime Medicine and Christian-Albrechts-University Kiel

Pieter- Jan A. M. van Ooij

Diving Medical Center, Royal Netherlands Navy, Den Helder, and Respiratory Department of the Academic Medical Center