Association of multimorbidity with guideline-directed medical therapy intensification in heart failure: Findings from the EPIC-HF trial

Jonathan Lipsey; Larry A. Allen; Robert L. Page; Laura J. Helmkamp; Grace Venechuk; Katy E. Trinkley; Daniel D. Matlock; Colleen K. McIlvennan

Heliyon (Jul 2024)

Association of multimorbidity with guideline-directed medical therapy intensification in heart failure: Findings from the EPIC-HF trial

Jonathan Lipsey,
Larry A. Allen,
Robert L. Page,
Laura J. Helmkamp,
Grace Venechuk,
Katy E. Trinkley,
Daniel D. Matlock,
Colleen K. McIlvennan

Affiliations

Jonathan Lipsey: Division of Cardiology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Larry A. Allen: Division of Cardiology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Robert L. Page: Division of Cardiology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Laura J. Helmkamp: Division of Cardiology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Grace Venechuk: Division of Cardiology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Katy E. Trinkley: Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Science, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Daniel D. Matlock: Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA; VA Eastern Colorado Geriatric Research Education and Clinical Center, Denver, CO, USA; Adult and Child Consortium for Outcomes Research and Delivery Science, USA
Colleen K. McIlvennan: Division of Cardiology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Corresponding author. ClinicalTrials.gov University of Colorado, School of Medicine 12631 East 17th Avenue, B130 Aurora, CO, 80045, USA.

Journal volume & issue: Vol. 10, no. 13
p. e34178

Abstract

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A potential contributor to the suboptimal rates of guideline directed medical therapy (GDMT) prescribing for heart failure with reduced ejection fraction (HFrEF) is the burden of multimorbidity in patients with HFrEF. We examined the effect of multimorbidity on GDMT prescription in the EPIC-HF trial, finding that multimorbidity was associated with decreased likelihood of GDMT intensification. Further study is needed to guide treatment in high-risk, multimorbid patients with HFrEF.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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