Nature Communications (Jan 2021)
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
- Kathryn A. Ryan,
- Kevin R. Bewley,
- Susan A. Fotheringham,
- Gillian S. Slack,
- Phillip Brown,
- Yper Hall,
- Nadina I. Wand,
- Anthony C. Marriott,
- Breeze E. Cavell,
- Julia A. Tree,
- Lauren Allen,
- Marilyn J. Aram,
- Thomas J. Bean,
- Emily Brunt,
- Karen R. Buttigieg,
- Daniel P. Carter,
- Rebecca Cobb,
- Naomi S. Coombes,
- Steve J. Findlay-Wilson,
- Kerry J. Godwin,
- Karen E. Gooch,
- Jade Gouriet,
- Rachel Halkerston,
- Debbie J. Harris,
- Thomas H. Hender,
- Holly E. Humphries,
- Laura Hunter,
- Catherine M. K. Ho,
- Chelsea L. Kennard,
- Stephanie Leung,
- Stephanie Longet,
- Didier Ngabo,
- Karen L. Osman,
- Jemma Paterson,
- Elizabeth J. Penn,
- Steven T. Pullan,
- Emma Rayner,
- Oliver Skinner,
- Kimberley Steeds,
- Irene Taylor,
- Tom Tipton,
- Stephen Thomas,
- Carrie Turner,
- Robert J. Watson,
- Nathan R. Wiblin,
- Sue Charlton,
- Bassam Hallis,
- Julian A. Hiscox,
- Simon Funnell,
- Mike J. Dennis,
- Catherine J. Whittaker,
- Michael G. Catton,
- Julian Druce,
- Francisco J. Salguero,
- Miles W. Carroll
Affiliations
- Kathryn A. Ryan
- National Infection Service, Public Health England (PHE)
- Kevin R. Bewley
- National Infection Service, Public Health England (PHE)
- Susan A. Fotheringham
- National Infection Service, Public Health England (PHE)
- Gillian S. Slack
- National Infection Service, Public Health England (PHE)
- Phillip Brown
- National Infection Service, Public Health England (PHE)
- Yper Hall
- National Infection Service, Public Health England (PHE)
- Nadina I. Wand
- National Infection Service, Public Health England (PHE)
- Anthony C. Marriott
- National Infection Service, Public Health England (PHE)
- Breeze E. Cavell
- National Infection Service, Public Health England (PHE)
- Julia A. Tree
- National Infection Service, Public Health England (PHE)
- Lauren Allen
- National Infection Service, Public Health England (PHE)
- Marilyn J. Aram
- National Infection Service, Public Health England (PHE)
- Thomas J. Bean
- National Infection Service, Public Health England (PHE)
- Emily Brunt
- National Infection Service, Public Health England (PHE)
- Karen R. Buttigieg
- National Infection Service, Public Health England (PHE)
- Daniel P. Carter
- National Infection Service, Public Health England (PHE)
- Rebecca Cobb
- National Infection Service, Public Health England (PHE)
- Naomi S. Coombes
- National Infection Service, Public Health England (PHE)
- Steve J. Findlay-Wilson
- National Infection Service, Public Health England (PHE)
- Kerry J. Godwin
- National Infection Service, Public Health England (PHE)
- Karen E. Gooch
- National Infection Service, Public Health England (PHE)
- Jade Gouriet
- National Infection Service, Public Health England (PHE)
- Rachel Halkerston
- National Infection Service, Public Health England (PHE)
- Debbie J. Harris
- National Infection Service, Public Health England (PHE)
- Thomas H. Hender
- National Infection Service, Public Health England (PHE)
- Holly E. Humphries
- National Infection Service, Public Health England (PHE)
- Laura Hunter
- National Infection Service, Public Health England (PHE)
- Catherine M. K. Ho
- National Infection Service, Public Health England (PHE)
- Chelsea L. Kennard
- National Infection Service, Public Health England (PHE)
- Stephanie Leung
- National Infection Service, Public Health England (PHE)
- Stephanie Longet
- National Infection Service, Public Health England (PHE)
- Didier Ngabo
- National Infection Service, Public Health England (PHE)
- Karen L. Osman
- National Infection Service, Public Health England (PHE)
- Jemma Paterson
- National Infection Service, Public Health England (PHE)
- Elizabeth J. Penn
- National Infection Service, Public Health England (PHE)
- Steven T. Pullan
- National Infection Service, Public Health England (PHE)
- Emma Rayner
- National Infection Service, Public Health England (PHE)
- Oliver Skinner
- National Infection Service, Public Health England (PHE)
- Kimberley Steeds
- National Infection Service, Public Health England (PHE)
- Irene Taylor
- National Infection Service, Public Health England (PHE)
- Tom Tipton
- National Infection Service, Public Health England (PHE)
- Stephen Thomas
- National Infection Service, Public Health England (PHE)
- Carrie Turner
- National Infection Service, Public Health England (PHE)
- Robert J. Watson
- National Infection Service, Public Health England (PHE)
- Nathan R. Wiblin
- National Infection Service, Public Health England (PHE)
- Sue Charlton
- National Infection Service, Public Health England (PHE)
- Bassam Hallis
- National Infection Service, Public Health England (PHE)
- Julian A. Hiscox
- Institute of Infection and Global Health, University of Liverpool
- Simon Funnell
- National Infection Service, Public Health England (PHE)
- Mike J. Dennis
- National Infection Service, Public Health England (PHE)
- Catherine J. Whittaker
- National Infection Service, Public Health England (PHE)
- Michael G. Catton
- Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity
- Julian Druce
- Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity
- Francisco J. Salguero
- National Infection Service, Public Health England (PHE)
- Miles W. Carroll
- National Infection Service, Public Health England (PHE)
- DOI
- https://doi.org/10.1038/s41467-020-20439-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
SARS-CoV-2 induces mild infection in ferret model. Here, Ryan et al. characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shedding, and pathology in ferrets and finally provide evidence for protection after re-challenge.
