758 High-potency synthetic STING agonists rewire the myeloid stroma in the tumour microenvironment to amplify immune checkpoint blockade efficacy in refractory pancreatic ductal adenocarcinoma

• Casey Ager,
• Michael Curran,
• Philip Jones,
• Akash Boda,
• Kimal Rajapakshe,
• Spencer Lea,
• Maria Emilia Di Francesco

Affiliations

Casey Ager

Aff1 grid.240145.60000000122914776Department of ImmunologyUniversity of Texas MD Anderson Cancer Center Houston TX USA

Michael Curran

Aff1 grid.240145.60000000122914776Department of ImmunologyUniversity of Texas MD Anderson Cancer Center Houston TX USA

Philip Jones

5 Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Akash Boda

1 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Kimal Rajapakshe

4 Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Spencer Lea

1The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Maria Emilia Di Francesco

4UT MD Anderson Cancer Center, Houston, TX, United States