Nature Communications (Nov 2021)
Molecular programs of fibrotic change in aging human lung
- Seoyeon Lee,
- Mohammad Naimul Islam,
- Kaveh Boostanpour,
- Dvir Aran,
- Guangchun Jin,
- Stephanie Christenson,
- Michael A. Matthay,
- Walter L. Eckalbar,
- Daryle J. DePianto,
- Joseph R. Arron,
- Liam Magee,
- Sunita Bhattacharya,
- Rei Matsumoto,
- Masaru Kubota,
- Donna L. Farber,
- Jahar Bhattacharya,
- Paul J. Wolters,
- Mallar Bhattacharya
Affiliations
- Seoyeon Lee
- Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep, University of California
- Mohammad Naimul Islam
- Lung Biology Laboratory, Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Vagelos College of Physicians and Surgeons of Columbia University
- Kaveh Boostanpour
- Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep, University of California
- Dvir Aran
- Lorry I. Lokey Interdisciplinary Center for Life Sciences & Engineering, Technion Israel Institute of Technology
- Guangchun Jin
- Lung Biology Laboratory, Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Vagelos College of Physicians and Surgeons of Columbia University
- Stephanie Christenson
- Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep, University of California
- Michael A. Matthay
- Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep, University of California
- Walter L. Eckalbar
- Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep, University of California
- Daryle J. DePianto
- Genentech Research and Early Development, Genentech, Inc.
- Joseph R. Arron
- Genentech Research and Early Development, Genentech, Inc.
- Liam Magee
- Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep, University of California
- Sunita Bhattacharya
- Lung Biology Laboratory, Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Vagelos College of Physicians and Surgeons of Columbia University
- Rei Matsumoto
- Department of Surgery, Vagelos College of Physicians and Surgeons of Columbia University
- Masaru Kubota
- Department of Surgery, Vagelos College of Physicians and Surgeons of Columbia University
- Donna L. Farber
- Department of Surgery, Vagelos College of Physicians and Surgeons of Columbia University
- Jahar Bhattacharya
- Lung Biology Laboratory, Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Vagelos College of Physicians and Surgeons of Columbia University
- Paul J. Wolters
- Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep, University of California
- Mallar Bhattacharya
- Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep, University of California
- DOI
- https://doi.org/10.1038/s41467-021-26603-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Age is associated with increasing vulnerability to both acute and chronic lung diseases. Employing genomic analysis and live lung imaging, this study reveals a profile of increased cellular senescence, telomere shortening, and fibrosis-induced impaired alveolar function in the natural history of human lung aging.
