Eccrine Porocarcinoma Associated with an Eccrine Poroma

Abstract

Eccrine porocarcinoma is a rare carcinoma arising from the intraepidermal duct of eccrine sweat glands and constitute about 0.005% of epithelial cutaneous neoplasms. Eccrine porocarcinoma is commonly seen in lower extremities, followed by head, scalp, upper extremities, trunk and abdomen. It can arise denovo or from pre-existing eccrine poroma in 18% of cases. We present a 45 years old female patient who presented with painful hard warty growth of size 3x2 cm with ulceration and an adjacent nodule measuring 1x1 cm in the lateral aspect of dorsum of left foot for the past 3 years with rapid increase in size for 3 months duration. Microscopically larger and smaller nodules showed features of eccrine porocarcinoma and eccrine poroma respectively. Immunohistochemistry for pancytokeratin showed strong membrane positivity, Ki-67 showed 40% nuclear positivity and CD 34 negative. The lesion was diagnosed microscopically as eccrine porocarcinoma associated with pre-existing eccrine poroma.

Keywords

• Eccrine porocarcinoma
• Sweat gland carcinoma
• Malignant eccrine poroma