Communications Biology (May 2022)
Neocortical localization and thalamocortical modulation of neuronal hyperexcitability contribute to Fragile X Syndrome
- Ernest V. Pedapati,
- Lauren M. Schmitt,
- Lauren E. Ethridge,
- Makoto Miyakoshi,
- John A. Sweeney,
- Rui Liu,
- Elizabeth Smith,
- Rebecca C. Shaffer,
- Kelli C. Dominick,
- Donald L. Gilbert,
- Steve W. Wu,
- Paul S. Horn,
- Devin K. Binder,
- Martine Lamy,
- Megan Axford,
- Craig A. Erickson
Affiliations
- Ernest V. Pedapati
- Division of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center
- Lauren M. Schmitt
- Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center
- Lauren E. Ethridge
- Department of Pediatrics, Section on Developmental and Behavioral Pediatrics, University of Oklahoma Health Sciences Center
- Makoto Miyakoshi
- Swartz Center for Computational Neuroscience, Institute for Neural Computation, University of California San Diego
- John A. Sweeney
- Department of Psychiatry, University of Cincinnati College of Medicine
- Rui Liu
- Division of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center
- Elizabeth Smith
- Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center
- Rebecca C. Shaffer
- Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center
- Kelli C. Dominick
- Division of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center
- Donald L. Gilbert
- Division of Neurology, Cincinnati Children’s Hospital Medical Center
- Steve W. Wu
- Division of Neurology, Cincinnati Children’s Hospital Medical Center
- Paul S. Horn
- Division of Neurology, Cincinnati Children’s Hospital Medical Center
- Devin K. Binder
- Division of Biomedical Sciences, School of Medicine, University of California
- Martine Lamy
- Division of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center
- Megan Axford
- Division of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center
- Craig A. Erickson
- Division of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center
- DOI
- https://doi.org/10.1038/s42003-022-03395-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
A large EEG dataset from 70 patients with Fragile X syndrome reveals unique changes in neural activity and highlight the role for disrupted thalamocortical modulation in local hyperexcitability.
