JACC: Basic to Translational Science (Apr 2016)
Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes
- Yoshio Takemoto, MD, PhD,
- Rafael J. Ramirez, PhD,
- Miki Yokokawa, MD,
- Kuljeet Kaur, PhD,
- Daniela Ponce-Balbuena, PhD,
- Mohamad C. Sinno, MD,
- B. Cicero Willis, MD,
- Hamid Ghanbari, MD,
- Steven R. Ennis, PhD,
- Guadalupe Guerrero-Serna, PhD,
- Bettina C. Henzi, MD,
- Rakesh Latchamsetty, MD,
- Roberto Ramos-Mondragon, PhD,
- Hassan Musa, PhD,
- Raphael P. Martins, MD,
- Sandeep V. Pandit, PhD,
- Sami F. Noujaim, PhD,
- Thomas Crawford, MD,
- Krit Jongnarangsin, MD,
- Frank Pelosi, MD,
- Frank Bogun, MD,
- Aman Chugh, MD,
- Omer Berenfeld, PhD,
- Fred Morady, MD,
- Hakan Oral, MD,
- José Jalife, MD
Affiliations
- Yoshio Takemoto, MD, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Rafael J. Ramirez, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Miki Yokokawa, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- Kuljeet Kaur, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Daniela Ponce-Balbuena, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Mohamad C. Sinno, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- B. Cicero Willis, MD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Hamid Ghanbari, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- Steven R. Ennis, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Guadalupe Guerrero-Serna, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Bettina C. Henzi, MD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Rakesh Latchamsetty, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- Roberto Ramos-Mondragon, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Hassan Musa, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Raphael P. Martins, MD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Sandeep V. Pandit, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Sami F. Noujaim, PhD
- Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts
- Thomas Crawford, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- Krit Jongnarangsin, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- Frank Pelosi, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- Frank Bogun, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- Aman Chugh, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- Omer Berenfeld, PhD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- Fred Morady, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- Hakan Oral, MD
- Division of Cardiovascular Medicine, Cardiac Arrhythmia Service, University of Michigan, Ann Arbor, Michigan
- José Jalife, MD
- Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan
- DOI
- https://doi.org/10.1016/j.jacbts.2016.03.003
- Journal volume & issue
-
Vol. 1,
no. 3
pp. 143 – 154
Abstract
Atrial fibrillation (AF) usually starts as paroxysmal but can evolve relentlessly to the persistent and permanent forms. However, the mechanisms governing such a transition are unknown. The authors show that intracardiac serum levels of galectin (Gal)-3 are greater in patients with persistent than paroxysmal AF and that Gal-3 independently predicts atrial tachyarrhythmia recurrences after a single ablation procedure. Using a sheep model of persistent AF the authors further demonstrate that upstream therapy targeting Gal-3 diminishes both electrical remodeling and fibrosis by impairing transforming growth factor beta–mediated signaling and reducing myofibroblast activation. Accordingly, Gal-3 inhibition therapy increases the probability of AF termination and reduces the overall burden of AF. Therefore the authors postulate that Gal-3 inhibition is a potential new upstream therapy to prevent AF progression.
Keywords
