Malignant hyperthermia

Abstract

Malignant hyperthermia manifests as hypermetabolism of striated voluntary muscle. Generally, this condition occurs during general anesthesia when inhalational anesthetics and succinylcholine are used. During the malignant hyperthermia attack, the oxygen consumption increases, lactate accumulates, the production of CO2 grows and excessive heat is generated. The crisis of malignant hyperthermia is a dangerous and potentially terminal complication of general anesthesia that requires rapid resolution in the shortest possible time. The only drug that can stop the acute state of malignant hyperthermia – dantrolen, is currently prohibited for import in Russia and is not legalized. Treatment of malignant hyperthermia is extremely difficult for all anesthesiologists in Russia and a great danger for patients with this condition.

Keywords

• treatment and diagnostisc of malignant hyperthermia
• dantrolen