Nature Communications (Jan 2020)

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

  • Emily E. Burke,
  • Joshua G. Chenoweth,
  • Joo Heon Shin,
  • Leonardo Collado-Torres,
  • Suel-Kee Kim,
  • Nicola Micali,
  • Yanhong Wang,
  • Carlo Colantuoni,
  • Richard E. Straub,
  • Daniel J. Hoeppner,
  • Huei-Ying Chen,
  • Alana Sellers,
  • Kamel Shibbani,
  • Gregory R. Hamersky,
  • Marcelo Diaz Bustamante,
  • BaDoi N. Phan,
  • William S. Ulrich,
  • Cristian Valencia,
  • Amritha Jaishankar,
  • Amanda J. Price,
  • Anandita Rajpurohit,
  • Stephen A. Semick,
  • Roland W. Bürli,
  • James C. Barrow,
  • Daniel J. Hiler,
  • Stephanie C. Page,
  • Keri Martinowich,
  • Thomas M. Hyde,
  • Joel E. Kleinman,
  • Karen F. Berman,
  • Jose A. Apud,
  • Alan J. Cross,
  • Nicholas J. Brandon,
  • Daniel R. Weinberger,
  • Brady J. Maher,
  • Ronald D. G. McKay,
  • Andrew E. Jaffe

DOI
https://doi.org/10.1038/s41467-019-14266-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes results in mutually synergistic maturation.