Nature Communications (Jul 2019)

Eradication of unresectable liver metastasis through induction of tumour specific energy depletion

  • Da Huo,
  • Jianfeng Zhu,
  • Guojun Chen,
  • Qian Chen,
  • Chao Zhang,
  • Xingyu Luo,
  • Wei Jiang,
  • Xiqun Jiang,
  • Zhen Gu,
  • Yong Hu

DOI
https://doi.org/10.1038/s41467-019-11082-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Treatment of liver metastasis in cancer patients is associated with severe side effects. Here, the authors develop nucleus and mitochondria targeted nanoparticles, conjugated via a cathepsin B sensitive peptide to selectively target liver metastatic cells.