Frontiers in Nutrition (Nov 2018)

Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study

  • Enza Speranza,
  • Iolanda Cioffi,
  • Lidia Santarpia,
  • Concetta Del Piano,
  • Carmela De Caprio,
  • Marianna Naccarato,
  • Maurizio Marra,
  • Emilia De Filippo,
  • Franco Contaldo,
  • Franco Contaldo,
  • Fabrizio Pasanisi,
  • Fabrizio Pasanisi

DOI
https://doi.org/10.3389/fnut.2018.00119
Journal volume & issue
Vol. 5

Abstract

Read online

Nutritional disorders such as Anorexia Nervosa (AN) can shape the composition of gut microbiota and its metabolites such as short chain fatty acid (SCFA). This study aims to compare fecal SCFA along with dietary intake of women with restrictive AN (r-AN = 10) and those of sex-matched lean controls (C = 8). The main fecal short chain fatty acids (SCFA) were assessed by gas chromatography equipped with a flame ionization detector. All participants completed 7-day food record and underwent indirect calorimetry for measuring resting energy expenditure (REE). Butyrate and propionate fecal concentrations were significantly reduced in r-AN patients compared to controls. The intake of carbohydrate and fat was significantly lower in r-AN patients than controls as well as energy intake and REE; whereas the amount of protein and fiber did not differ between groups. These preliminary results showed that r-AN patients had a reduced excretion of fecal SCFA, likely as a mechanism to compensate for the lower energy and carbohydrate intake observed between groups. Therefore, further studies need to be performed in patients with AN to explore the link between nutritional disorders, gut microbiota and its metabolites.

Keywords