Genomics Data (Dec 2014)

Changes in nucleosome occupancy occur in a chromosome specific manner

  • Brittany S. Sexton,
  • Brooke R. Druliner,
  • Denis Avey,
  • Fanxiu Zhu,
  • Jonathan H. Dennis

DOI
https://doi.org/10.1016/j.gdata.2014.06.006
Journal volume & issue
Vol. 2, no. C
pp. 114 – 116

Abstract

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In the eukaryotic nucleus, DNA is packaged into chromatin. The fundamental subunit of chromatin is the nucleosome, DNA is wrapped 1.6 times around a histone octamer core. Nuclear processes in eukaryotes are impacted by whether regulatory DNA is occupied by nucleosomes. We used microarrays to measure nucleosome occupancy in human cells post-Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation at hundreds of immunity-related loci. The detailed analysis of these technologies can be found in recent publications from our lab [1,3]. We found that nucleosome redistributions displayed chromosome specific nucleosome occupancy. This resource can be used to map nucleosome distributions in a variety of biological contexts.

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