NeuroImage: Clinical (Jan 2020)
Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium
- Yicheng Long,
- Hengyi Cao,
- Chaogan Yan,
- Xiao Chen,
- Le Li,
- Francisco Xavier Castellanos,
- Tongjian Bai,
- Qijing Bo,
- Guanmao Chen,
- Ningxuan Chen,
- Wei Chen,
- Chang Cheng,
- Yuqi Cheng,
- Xilong Cui,
- Jia Duan,
- Yiru Fang,
- Qiyong Gong,
- Wenbin Guo,
- Zhenghua Hou,
- Lan Hu,
- Li Kuang,
- Feng Li,
- Kaiming Li,
- Tao Li,
- Yansong Liu,
- Qinghua Luo,
- Huaqing Meng,
- Daihui Peng,
- Haitang Qiu,
- Jiang Qiu,
- Yuedi Shen,
- Yushu Shi,
- Tianmei Si,
- Chuanyue Wang,
- Fei Wang,
- Kai Wang,
- Li Wang,
- Xiang Wang,
- Ying Wang,
- Xiaoping Wu,
- Xinran Wu,
- Chunming Xie,
- Guangrong Xie,
- Haiyan Xie,
- Peng Xie,
- Xiufeng Xu,
- Hong Yang,
- Jian Yang,
- Jiashu Yao,
- Shuqiao Yao,
- Yingying Yin,
- Yonggui Yuan,
- Aixia Zhang,
- Hong Zhang,
- Kerang Zhang,
- Lei Zhang,
- Zhijun Zhang,
- Rubai Zhou,
- Yiting Zhou,
- Junjuan Zhu,
- Chaojie Zou,
- Yufeng Zang,
- Jingping Zhao,
- Calais Kin-yuen Chan,
- Weidan Pu,
- Zhening Liu
Affiliations
- Yicheng Long
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China; Mental Health Institute, Central South University, Changsha, Hunan 410011, China; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
- Hengyi Cao
- Department of Psychology, Yale University, 2 Hillhouse Avenue, New Haven, CT 06511, USA; Corresponding author at: Department of Psychology, Yale University, 2 Hillhouse Avenue, New Haven, CT 06511, USA.
- Chaogan Yan
- CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China; Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016, USA
- Xiao Chen
- CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
- Le Li
- CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
- Francisco Xavier Castellanos
- Department of Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016, USA; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
- Tongjian Bai
- The first affiliated hospital of Anhui Medical University, Hefei, Anhui 230022, China
- Qijing Bo
- Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
- Guanmao Chen
- The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China
- Ningxuan Chen
- CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
- Wei Chen
- Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China
- Chang Cheng
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China
- Yuqi Cheng
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
- Xilong Cui
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China
- Jia Duan
- Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China
- Yiru Fang
- Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
- Qiyong Gong
- Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
- Wenbin Guo
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China
- Zhenghua Hou
- Department of Psychosomatics and Psychiatry, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210096, China
- Lan Hu
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Li Kuang
- Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
- Feng Li
- Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
- Kaiming Li
- Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
- Tao Li
- Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
- Yansong Liu
- Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu 215137, China
- Qinghua Luo
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Huaqing Meng
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Daihui Peng
- Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
- Haitang Qiu
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Jiang Qiu
- Faculty of Psychology, Southwest University, Chongqing 400716, China
- Yuedi Shen
- Department of Diagnostics, Affiliated Hospital, Medical School, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China
- Yushu Shi
- Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
- Tianmei Si
- National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China
- Chuanyue Wang
- Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
- Fei Wang
- Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China
- Kai Wang
- The first affiliated hospital of Anhui Medical University, Hefei, Anhui 230022, China
- Li Wang
- National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China
- Xiang Wang
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China
- Ying Wang
- The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China
- Xiaoping Wu
- Xi'an Central Hospital, Xi'an, Shaanxi 710003, China
- Xinran Wu
- Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
- Chunming Xie
- Department of Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, China
- Guangrong Xie
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China
- Haiyan Xie
- Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
- Peng Xie
- Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Xiufeng Xu
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
- Hong Yang
- Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
- Jian Yang
- The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China
- Jiashu Yao
- Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China
- Shuqiao Yao
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China
- Yingying Yin
- Department of Psychosomatics and Psychiatry, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210096, China
- Yonggui Yuan
- Department of Psychosomatics and Psychiatry, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210096, China
- Aixia Zhang
- First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China
- Hong Zhang
- Xi'an Central Hospital, Xi'an, Shaanxi 710003, China
- Kerang Zhang
- First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China
- Lei Zhang
- CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
- Zhijun Zhang
- Xi'an Central Hospital, Xi'an, Shaanxi 710003, China
- Rubai Zhou
- Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
- Yiting Zhou
- Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
- Junjuan Zhu
- Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
- Chaojie Zou
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
- Yufeng Zang
- Center for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang 311121, China
- Jingping Zhao
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China
- Calais Kin-yuen Chan
- Department of Psychology, The University of Hong Kong, Hong Kong 999077, China
- Weidan Pu
- Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
- Zhening Liu
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China; Mental Health Institute, Central South University, Changsha, Hunan 410011, China; Corresponding author at: Department of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.
- Journal volume & issue
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Vol. 26
Abstract
Background: Major depressive disorder (MDD) is known to be characterized by altered brain functional connectivity (FC) patterns. However, whether and how the features of dynamic FC would change in patients with MDD are unclear. In this study, we aimed to characterize dynamic FC in MDD using a large multi-site sample and a novel dynamic network-based approach. Methods: Resting-state functional magnetic resonance imaging (fMRI) data were acquired from a total of 460 MDD patients and 473 healthy controls, as a part of the REST-meta-MDD consortium. Resting-state dynamic functional brain networks were constructed for each subject by a sliding-window approach. Multiple spatio-temporal features of dynamic brain networks, including temporal variability, temporal clustering and temporal efficiency, were then compared between patients and healthy subjects at both global and local levels. Results: The group of MDD patients showed significantly higher temporal variability, lower temporal correlation coefficient (indicating decreased temporal clustering) and shorter characteristic temporal path length (indicating increased temporal efficiency) compared with healthy controls (corrected p < 3.14×10−3). Corresponding local changes in MDD were mainly found in the default-mode, sensorimotor and subcortical areas. Measures of temporal variability and characteristic temporal path length were significantly correlated with depression severity in patients (corrected p < 0.05). Moreover, the observed between-group differences were robustly present in both first-episode, drug-naïve (FEDN) and non-FEDN patients. Conclusions: Our findings suggest that excessive temporal variations of brain FC, reflecting abnormal communications between large-scale bran networks over time, may underlie the neuropathology of MDD.
