Respiratory Medicine Case Reports (Jan 2020)

Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case

  • Yuichi Adachi,
  • Takayuki Takimoto,
  • Maiko Takeda,
  • Kinnosuke Matsumoto,
  • Naoko Takeuchi,
  • Tomoko Kagawa,
  • Tetsuki Sakamoto,
  • Takahiko Kasai,
  • Chikatoshi Sugimoto,
  • Yasushi Inoue,
  • Kazunobu Tachibana,
  • Toru Arai,
  • Yoshikazu Inoue

Journal volume & issue
Vol. 31
p. 101313

Abstract

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A 60-year-old man was admitted for ground glass opacity in the lower lung field and mediastinal lymphadenopathy. Blood tests revealed elevated serum IgM levels, and the urine test detected Bence-Jones protein. Surgical biopsy from the mediastinal lymph node and lung showed small lymphocytes and plasma cells between follicles, and AL kappa amyloid deposition. Genetic examination detected MYD88 L265P mutation. Our diagnosis was lymphoplasmacytic lymphoma (LPL), involving the mediastinum and the lung, followed by amyloidosis. Mutation analysis, in addition to conventional histological evaluation, was useful for a precise diagnosis.

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