44 Corticosteroids decrease efficacy of immune checkpoint inhibitor therapy and correlate with compromised CD8+ T-cell differentiation in patients with non-small cell lung cancer

• Rajeev Sharma,
• Hongbin Chen,
• Takaaki Oba,
• Fumito Ito,
• Kristopher Attwood,
• Grace Dy,
• Eihab Abdelfatah,
• Lauren Polyakov,
• Joy Sarkar,
• Brahm Segal

Affiliations

Rajeev Sharma

4University at Buffalo Jacobs School of Medicine and Biomedical Sciences, the State University of New York, Buffalo, NY, USA

Hongbin Chen

Aff2 Roswell Park Comprehensive Cancer Center Elm and Carlton Streets 14206 Buffalo NY USA

Takaaki Oba

Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA

Fumito Ito

2Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

Kristopher Attwood

Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA

Grace Dy

2Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

Eihab Abdelfatah

4Department of Surgery, The Johns Hopkins Hospital, Baltimore, Maryland, USA

Lauren Polyakov

1University of Southern California, Los Angeles, CA, USA

Joy Sarkar

2Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

Brahm Segal

2Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA