Nature Communications (Oct 2021)
Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
- Mads Delbo Larsen,
- Mary Lopez-Perez,
- Emmanuel Kakra Dickson,
- Paulina Ampomah,
- Nicaise Tuikue Ndam,
- Jan Nouta,
- Carolien A. M. Koeleman,
- Agnes L. Hipgrave Ederveen,
- Benjamin Mordmüller,
- Ali Salanti,
- Morten Agertoug Nielsen,
- Achille Massougbodji,
- C. Ellen van der Schoot,
- Michael F. Ofori,
- Manfred Wuhrer,
- Lars Hviid,
- Gestur Vidarsson
Affiliations
- Mads Delbo Larsen
- Department of Experimental Immunohematology, Sanquin Research
- Mary Lopez-Perez
- Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
- Emmanuel Kakra Dickson
- Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana
- Paulina Ampomah
- Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast
- Nicaise Tuikue Ndam
- Université de Paris, MERIT, IRD
- Jan Nouta
- Center for Proteomics and Metabolomics, Leiden University Medical Center
- Carolien A. M. Koeleman
- Center for Proteomics and Metabolomics, Leiden University Medical Center
- Agnes L. Hipgrave Ederveen
- Center for Proteomics and Metabolomics, Leiden University Medical Center
- Benjamin Mordmüller
- Department of Medical Microbiology, Radboud University Medical Center
- Ali Salanti
- Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
- Morten Agertoug Nielsen
- Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
- Achille Massougbodji
- Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l’Enfance (CERPAGE), Faculté des Sciences de la Santé, Université d’Abomey-Calavi
- C. Ellen van der Schoot
- Department of Experimental Immunohematology, Sanquin Research
- Michael F. Ofori
- Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana
- Manfred Wuhrer
- Center for Proteomics and Metabolomics, Leiden University Medical Center
- Lars Hviid
- Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
- Gestur Vidarsson
- Department of Experimental Immunohematology, Sanquin Research
- DOI
- https://doi.org/10.1038/s41467-021-26118-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Here, Larsen et al. describe differences in Fc fucosylation of P. falciparum PfEMP1-specific IgG produced in response to natural infection versus VAR2CSA-type subunit vaccination, which leads to differences in the ability to induce FcγRIIIa-dependent natural killer cell degranulation.
