Nature Communications (Feb 2022)
Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response
- Denise Chan,
- Phillip R. Bennett,
- Yun S. Lee,
- Samit Kundu,
- T. G. Teoh,
- Malko Adan,
- Saqa Ahmed,
- Richard G. Brown,
- Anna L. David,
- Holly V. Lewis,
- Belen Gimeno-Molina,
- Jane E. Norman,
- Sarah J. Stock,
- Vasso Terzidou,
- Pascale Kropf,
- Marina Botto,
- David A. MacIntyre,
- Lynne Sykes
Affiliations
- Denise Chan
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Phillip R. Bennett
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Yun S. Lee
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Samit Kundu
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- T. G. Teoh
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Malko Adan
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Saqa Ahmed
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Richard G. Brown
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Anna L. David
- Elizabeth Garrett Anderson Institute for Women’s Health, University College London
- Holly V. Lewis
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Belen Gimeno-Molina
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Jane E. Norman
- University of Edinburgh Usher Institute
- Sarah J. Stock
- University of Edinburgh Usher Institute
- Vasso Terzidou
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Pascale Kropf
- March of Dimes Prematurity Research Center at Imperial College London
- Marina Botto
- March of Dimes Prematurity Research Center at Imperial College London
- David A. MacIntyre
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Lynne Sykes
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-022-28620-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Gaining mechanistic insight into the microbiological and immunological factors that are associated with spontaneous preterm birth is important for the development of prevention strategies. Here authors show that the complement system in conjunction with specific vaginal microbial and associated immunological changes are contributing to this condition.
