CHL1 and NrCAM are primarily expressed in low grade pediatric neuroblastoma

Abstract

Neural cell adhesion molecules like close homolog of L1 protein (CHL1) and neuronal glia related cell adhesion molecule (NrCAM) play an important role in development and regeneration of the central nervous system. However, they are also associated with cancerogenesis and progression in adult malignancies, thus gain increasing importance in cancer research. We therefore studied the expression of CHL1 and NrCAM according to the course of disease in children with neuroblastoma.

Keywords

• chl1
• nrcam
• neuroblastoma
• immunohistochemistry
• tumor markers
• neuropathology