Abnormalities in gut virome signatures linked with cognitive impairment in older adults

Adewale S. James; Noorul A. Adil; Dayna Goltz; Divyani Tangudu; Diptaraj S. Chaudhari; Rohit Shukla; Vivek Kumar; Ambuj Kumar; Michal M. Masternak; Peter Holland; Corinne Labyak; Adam Golden; Mariana Dangiolo; Andrea Y. Arikawa; Judyta Kociolek; Amoy Fraser; Cynthia Williams; Marc Agronin; Mariolga Aymat; Shalini Jain; Hariom Yadav

doi:10.1080/19490976.2024.2431648

Gut Microbes (Dec 2024)

Abnormalities in gut virome signatures linked with cognitive impairment in older adults

Adewale S. James,
Noorul A. Adil,
Dayna Goltz,
Divyani Tangudu,
Diptaraj S. Chaudhari,
Rohit Shukla,
Vivek Kumar,
Ambuj Kumar,
Michal M. Masternak,
Peter Holland,
Corinne Labyak,
Adam Golden,
Mariana Dangiolo,
Andrea Y. Arikawa,
Judyta Kociolek,
Amoy Fraser,
Cynthia Williams,
Marc Agronin,
Mariolga Aymat,
Shalini Jain,
Hariom Yadav

Affiliations

Adewale S. James: USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Noorul A. Adil: USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Dayna Goltz: USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Divyani Tangudu: USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Diptaraj S. Chaudhari: USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Rohit Shukla: USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Vivek Kumar: USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Ambuj Kumar: Research Methodology and Biostatistics, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Michal M. Masternak: School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA
Peter Holland: Department of Neuroscience, FAU Schmidt College of Medicine/i-Health FAU, Boca Raton, FL, USA
Corinne Labyak: Department of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA
Adam Golden: School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA
Mariana Dangiolo: School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA
Andrea Y. Arikawa: Department of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA
Judyta Kociolek: Department of Neuroscience, FAU Schmidt College of Medicine/i-Health FAU, Boca Raton, FL, USA
Amoy Fraser: School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA
Cynthia Williams: School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA
Marc Agronin: Behavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, USA
Mariolga Aymat: Behavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, USA
Shalini Jain: USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Hariom Yadav: USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA

DOI: https://doi.org/10.1080/19490976.2024.2431648
Journal volume & issue: Vol. 16, no. 1

Abstract

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Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to aging and cognitive function, remain poorly understood. Here, we present proof-of-concept results from a pilot study using datasets (n = 176) from the Microbiome in Aging Gut and Brain (MiaGB) consortium, demonstrating that the human virome signature significantly differs across the aging continuum (60s vs. 70s vs. 80+ years of age) in older adults. We observed that the predominant virome signature was enriched with bacteriophages, which change considerably with aging continuum. Analyses of interactions between phages and the host bacteriome suggest that lytic or temperate relationships change distinctly across the aging continuum, as well as cognitive impairment. Interestingly, the phage-bacteriome-metabolome interactions develop unique patterns that are distinctly linked to aging and cognitive dysfunction in older adults. The phage-bacteriome interactions affect bacterial metabolic pathways, potentially impacting older adults’ health, including the risk of cognitive decline and dementia. Further comprehension of these studies could provide opportunities to target the microbiome by developing phage therapies to improve aging and brain health in older adults.

Published in Gut Microbes

ISSN: 1949-0976 (Print); 1949-0984 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.tandfonline.com/journals/kgmi

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