Fatty acid methyl esters as a potential therapy against cerebral ischemia

Hui-Chao Lee Reggie; Goyanes Vasquez Juan Jose; Couto e Silva Alexandre; Klein Daniel D.; Valido Stephen E.; Chen Joseph A.; Lerner Francesca M.; Neumann Jake T.; Yin-Chieh Wu Celeste; Wen Lin Hung

doi:10.1051/ocl/2015040

Oilseeds and fats, crops and lipids (Jan 2016)

Fatty acid methyl esters as a potential therapy against cerebral ischemia

Hui-Chao Lee Reggie,
Goyanes Vasquez Juan Jose,
Couto e Silva Alexandre,
Klein Daniel D.,
Valido Stephen E.,
Chen Joseph A.,
Lerner Francesca M.,
Neumann Jake T.,
Yin-Chieh Wu Celeste,
Wen Lin Hung

Affiliations

Hui-Chao Lee Reggie: Cerebral Vascular Disease Laboratories, Department of Neurology, University of Miami Miller School of Medicine
Goyanes Vasquez Juan Jose: Cerebral Vascular Disease Laboratories, Department of Neurology, University of Miami Miller School of Medicine
Couto e Silva Alexandre: Cerebral Vascular Disease Laboratories, Department of Neurology, University of Miami Miller School of Medicine
Klein Daniel D.: Cerebral Vascular Disease Laboratories, Department of Neurology, University of Miami Miller School of Medicine
Valido Stephen E.: Cerebral Vascular Disease Laboratories, Department of Neurology, University of Miami Miller School of Medicine
Chen Joseph A.: Cerebral Vascular Disease Laboratories, Department of Neurology, University of Miami Miller School of Medicine
Lerner Francesca M.: Cerebral Vascular Disease Laboratories, Department of Neurology, University of Miami Miller School of Medicine
Neumann Jake T.: Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine
Yin-Chieh Wu Celeste: Cerebral Vascular Disease Laboratories, Department of Neurology, University of Miami Miller School of Medicine
Wen Lin Hung: Cerebral Vascular Disease Laboratories, Department of Neurology, University of Miami Miller School of Medicine

DOI: https://doi.org/10.1051/ocl/2015040
Journal volume & issue: Vol. 23, no. 1
p. D108

Abstract

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Saturated fatty acids have been traditionally thought to be detrimental in circulation. However, we describe the beneficial effects of palmitic and stearic acid methyl esters as it relates to neuroprotection and cerebral vasodilatory properties in global and focal cerebral ischemia. The methyl esterification of fatty acids is not prominent in nature. However, it seems to have biological activity related to neuroprotection/vasodilation. We will discuss the etiology of cerebral ischemia such as stroke and cardiac arrest in terms of current and future treatment modalitiesas it relates to fatty acid-based therapies. This review is based on the meeting presentation at the “The Journées Chevreul, Lipids & Brain III 2015” in Paris on 16–18 March, 2015.

Published in Oilseeds and fats, crops and lipids

ISSN: 2272-6977 (Print); 2257-6614 (Online)
Publisher: EDP Sciences
Country of publisher: France
LCC subjects: Technology: Chemical technology: Oils, fats, and waxes
Website: http://www.ocl-journal.org/

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Abstract

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