BMJ Open (Dec 2020)

C-reactive protein at discharge and 1-year mortality in hospitalised patients with acute decompensated heart failure: an observational study

  • Takeshi Kitai,
  • Yutaka Furukawa,
  • Takeshi Morimoto,
  • Kenji Ando,
  • Yuichi Kawase,
  • Masashi Kato,
  • Kazuya Nagao,
  • Mamoru Toyofuku,
  • Takao Kato,
  • Moriaki Inoko,
  • Tomoyuki Ikeda,
  • Akihiro Komasa,
  • Yasutaka Inuzuka,
  • Toshikazu Jinnai,
  • Takeshi Kimura,
  • Koichiro Kuwahara,
  • Kazushige Kadota,
  • Yuta Seko,
  • Hidenori Yaku,
  • Yodo Tamaki,
  • Neiko Ozasa,
  • Erika Yamamoto,
  • Yusuke Yoshikawa,
  • Yoshihisa Nakagawa,
  • Yukihito Sato,
  • Koh Ono,
  • Yuji Nishimoto,
  • Ryoji Taniguchi,
  • Moritake Iguchi,
  • Mamoru Takahashi,
  • Takafumi Kawai,
  • Ryusuke Nishikawa,
  • Takashi Morinaga,
  • Kanae Su,
  • Mitsunori Kawato,
  • Satoshi Shizuta

DOI
https://doi.org/10.1136/bmjopen-2020-041068
Journal volume & issue
Vol. 10, no. 12

Abstract

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Objectives To examine the association of a high C-reactive protein (CRP) level at discharge from an acute decompensated heart failure (ADHF) hospitalisation with the 1-year clinical outcomes.Design A post-hoc subanalysis of a prospective cohort study of patients hospitalised for ADHF (using the Kyoto Congestive Heart Failure (KCHF) registry) between October 2014 and March 2016 with a 1-year follow-up.Setting A physician-initiated multicentre registry enrolled consecutive hospitalised patients with ADHF for the first time at 19 secondary and tertiary hospitals in Japan.Participants Among the 4056 patients enrolled in the KCHF registry, the present study population consisted of 2618 patients with an available CRP value both on admission and at discharge and post-discharge clinical follow-up data. We divided the patients into two groups, those with a high CRP level (>10 mg/L) and those with a low CRP level (≤10 mg/L) at discharge from the index hospitalisation.Primary and secondary outcome measures The primary outcome measure was all-cause death after discharge from the index hospitalisation. The secondary outcome measures were heart failure hospitalisations, cardiovascular death and non-cardiovascular death.Results The high CRP group and low CRP group included 622 patients (24%) and 1996 patients (76%), respectively. During a median follow-up period of 468 days, the cumulative 1-year incidence of the primary outcome was significantly higher in the high CRP group than low CRP group (24.1% vs 13.9%, log-rank p<0.001). Even after a multivariable analysis, the excess mortality risk in the high CRP group relative to the low CRP group remained significant (HR, 1.43; 95% CI, 1.19 to 1.71; p<0.001). The excess mortality risk was consistent regardless of the clinically relevant subgroup factors.Conclusions A high CRP level (>10 mg/L) at discharge from an ADHF hospitalisation was associated with an excess mortality risk at 1 year.Trial registration details https://clinicaltrials.gov/ct2/show/NCT02334891 (NCT02334891) https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017241 (UMIN000015238).