The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury

Mohammad Naimul Islam; Galina A. Gusarova; Shonit R. Das; Li Li; Eiji Monma; Murari Anjaneyulu; Liberty Mthunzi; Sadiqa K. Quadri; Edward Owusu-Ansah; Sunita Bhattacharya; Jahar Bhattacharya

doi:10.1038/s41467-022-33543-y

Nature Communications (Oct 2022)

The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury

Mohammad Naimul Islam,
Galina A. Gusarova,
Shonit R. Das,
Li Li,
Eiji Monma,
Murari Anjaneyulu,
Liberty Mthunzi,
Sadiqa K. Quadri,
Edward Owusu-Ansah,
Sunita Bhattacharya,
Jahar Bhattacharya

Affiliations

Mohammad Naimul Islam: Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Galina A. Gusarova: Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Shonit R. Das: Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Li Li: Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Eiji Monma: Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Murari Anjaneyulu: Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University
Liberty Mthunzi: Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Sadiqa K. Quadri: Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Edward Owusu-Ansah: Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University
Sunita Bhattacharya: Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University
Jahar Bhattacharya: Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University

DOI: https://doi.org/10.1038/s41467-022-33543-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Acute lung injury caused by inhalation of pathogens leads to mortality, but the mechanisms are unclear. Here, the authors show in mice that that loss of the mitochondrial calcium uniporter (MCU) of alveolar type 2 cells (AT2) impaired mitochondrial Ca2+ buffering and surfactant secretion, and increased mortality, in response to LPS instillation, suggesting the MCU as a potential therapeutic target in ALI.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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