Nature Communications (Jun 2020)

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling

  • Xiaoyun Sun,
  • Xixia Peng,
  • Yuqin Cao,
  • Yan Zhou,
  • Yuhua Sun

DOI
https://doi.org/10.1038/s41467-020-16799-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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ADNP has been connected to neural developmental disorders. Here, the authors uncover a role for ADNP in neural induction and differentiation via β-Catenin stabilization, with ADNP disruption in zebrafish leading to defective neurogenesis and decreased Wnt signaling.