Nature Communications (Dec 2017)
Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus
- C. David Owen,
- Louise E. Tailford,
- Serena Monaco,
- Tanja Šuligoj,
- Laura Vaux,
- Romane Lallement,
- Zahra Khedri,
- Hai Yu,
- Karine Lecointe,
- John Walshaw,
- Sandra Tribolo,
- Marc Horrex,
- Andrew Bell,
- Xi Chen,
- Gary L. Taylor,
- Ajit Varki,
- Jesus Angulo,
- Nathalie Juge
Affiliations
- C. David Owen
- Biomolecular Sciences Building, University of St Andrews
- Louise E. Tailford
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- Serena Monaco
- School of Pharmacy, University of East Anglia, Norwich Research Park
- Tanja Šuligoj
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- Laura Vaux
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- Romane Lallement
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- Zahra Khedri
- Glycobiology Research and Training Center (GRTC), Departments of Medicine and Cellular and Molecular Medicine, UC San Diego
- Hai Yu
- Department of Chemistry, University of California-Davis
- Karine Lecointe
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- John Walshaw
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- Sandra Tribolo
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- Marc Horrex
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- Andrew Bell
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- Xi Chen
- Department of Chemistry, University of California-Davis
- Gary L. Taylor
- Biomolecular Sciences Building, University of St Andrews
- Ajit Varki
- Glycobiology Research and Training Center (GRTC), Departments of Medicine and Cellular and Molecular Medicine, UC San Diego
- Jesus Angulo
- School of Pharmacy, University of East Anglia, Norwich Research Park
- Nathalie Juge
- The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park
- DOI
- https://doi.org/10.1038/s41467-017-02109-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
The mucus layer is an important physical niche within the gut which harbours a distinct microbial community. Here the authors show that specific carbohydrate-binding modules associated with bacterial carbohydrate-active enzymes are mucus adhesins that target regions of the distal colon rich in sialomucins.
