A unified approach to the important protein kinase inhibitor balanol and a proposed analogue

Abstract

A common approach to the important protein kinase inhibitor (−)-balanol and an azepine-ring-modified balanol derivative has been developed using an efficient fragment coupling protocol which proceeded in good overall yield.

Keywords

• azepane
• balanol
• Garner’s aldehyde
• PKC inhibitor
• ring-closing metathesis