Effect of Sulfated Polysaccharides from Brown Alga Fucus evanescens and Their Enzymatic Transformation Product on Functional Activity of Innate Immunity Cells

Abstract

The effect of sulfated polysaccharides (PS) from brown alga Fucus evanescens and their enzymatic transformation and low molecular weight product on the functional activity of the innate immunity cells, i.e. polymorphonuclear leukocytes of human peripheral blood (NF) was comparatively studied. The in vitro NF contact with PS resulted in significant changes in the functional activity of NF, evident from higher density of molecules CD69, CD14, CD11b on the cell membranes with simultaneous lowering of that of CD62L and increased phagocytic and bactericidal activity of NF. The low molecular weight product resulting from fucoidan transformation with fucoidanases showed a higher effect on the level of the molecules CD14, CD11b and CD62L expression vs. the high molecular weight PS.

Keywords

• sulfated polysaccharides
• fucoidans
• innate immunity
• neutrophils
• adhesion molecules
• phagocytic and bactericidal activity