Nature Communications (Jun 2017)

Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy

  • Yu-Cheng Su,
  • Pierre-Alain Burnouf,
  • Kuo-Hsiang Chuang,
  • Bing-Mae Chen,
  • Tian-Lu Cheng,
  • Steve R. Roffler

DOI
https://doi.org/10.1038/ncomms15507
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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The majority of treatment options for cancers are ineffective due to limited therapeutic targeting. Here, the authors develop bispecific antibodies that effectively target nanomaterials to triple-negative breast cancer cell receptors and deliver therapeutics leading to inhibition of tumour growth.