Severe chronic osteomyelitis caused by Morganella morganii with high population diversity

Jialiang Zhu; Haifeng Li; Li Feng; Min Yang; Ronggong Yang; Lin Yang; Li Li; Ruoyan Li; Minshan Liu; Shuxun Hou; Yuehua Ke; Wenfeng Li; Fan Bai

doi:10.1016/j.ijid.2016.07.016

International Journal of Infectious Diseases (Sep 2016)

Severe chronic osteomyelitis caused by Morganella morganii with high population diversity

Jialiang Zhu,
Haifeng Li,
Li Feng,
Min Yang,
Ronggong Yang,
Lin Yang,
Li Li,
Ruoyan Li,
Minshan Liu,
Shuxun Hou,
Yuehua Ke,
Wenfeng Li,
Fan Bai

Affiliations

Jialiang Zhu: Department of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China
Haifeng Li: Department of Medical Affairs, General Hospital of Beijing Military Region of PLA, Beijing, China
Li Feng: Department of Surgery Room, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, China
Min Yang: Construction Engineering Research Institute, Xi’an, Shaanxi Province, China
Ronggong Yang: Department of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China
Lin Yang: Department of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China
Li Li: Department of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China
Ruoyan Li: Biodynamic Optical Imaging Center, School of Life Science, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, China
Minshan Liu: Biodynamic Optical Imaging Center, School of Life Science, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, China
Shuxun Hou: Department of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China
Yuehua Ke: Institute of Disease Control and Prevention, AMMS, No. 20, Dongdajie, Fengtai District, Beijing 100071, China
Wenfeng Li: Department of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China
Fan Bai: Biodynamic Optical Imaging Center, School of Life Science, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, China

DOI: https://doi.org/10.1016/j.ijid.2016.07.016
Journal volume & issue: Vol. 50, no. C
pp. 44 – 47

Abstract

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A case of chronic osteomyelitis probably caused by Morganella morganii, occurring over a period of 30 years, is reported. The organism was identified through a combination of sample culture, direct sequencing, and 16S RNA gene amplicon sequencing. Further whole-genome sequencing and population structure analysis of the isolates from the patient showed the bacterial population to be highly diverse. This case provides a valuable example of a long-term infection caused by an opportunistic pathogen, M. morganii, with high diversity, which might evolve during replication within the host.

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

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