Facile syntheses of Mannich bases of 3-[p-(5-arylpyrazolin-3-yl)phenyl]sydnones, as anti-tubercular and anti-microbial agents, under ionic liquid/tetrabutylammonium bromide catalytic conditions

Abstract

Novel methylene bridged Mannich bases 2a–j were synthesized in good to excellent yields from the pyrazoline derivative 1 using various pri­ma­ry/secondary amines, 37 % formalin in presence of ionic liquids/TBAB as ca­talyst. The structures of the newly synthesized compounds were confirmed by IR, 1H- and 13C-NMR and GC–MS spectroscopy, as well as elemental ana­lysis. The title compounds were screened for their anti-tubercular and antimic­robial activities. Some of the compounds exhibited very good anti-tubercular, antifun­gal and antibacterial activities.

Keywords

• pyrazoline
• Mannich base
• ionic liquids
• TBAB
• MIC
• anti-tuber­cu­lar activity