Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

Abstract

In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).

Keywords

• nefiracetam
• solid state
• cocrystals
• solubility
• dissolution rate
• stability