Research progress of SIRT1 as a target for the treatment of age-related retinal disease

Abstract

Silent information regulator protein 1(SIRT1)is one of the sirtuins and belongs to histone deacetyase. Its activity depends on nicotinamide adenine dinucleotide(NAD+)and is regulated by NAD+. Experimental and clinical studies have shown the neuro-protective effect of SIRT1 in the pathogenesis of age-related eye diseases. In this review, the relationship between SIRT1 activator and apoptosis in the retinal cells were discussed. The review also points to SIRT1 as a potential therapeutic target for the clinical management of age-related retinal disease.

Keywords

• silent information regulator protein 1
• neuro-protective effect
• research progression
• age-related retinal disease