MAMMALIAN MODELS OF PATHOGEN-ASSOCIATED MUSCLE DEGENERATION

Abstract

Studies on pathogen-associated muscle degeneration (PAMD) seem not to progress despite the recent advancements in omics. The limited and outdated literature about pathogen-associated muscle degeneration in different animal models contradicts the thorough understanding of their genome. In this paper, we review the pathophysiology of pathogen infection through association with the physiologic, biochemical, and molecular changes happening in the skeletal, cardiac, and smooth muscles of different well-established mammalian models, namely rats (Rattus sp.), mice (Mus musculus), and rabbit (Oryctolagus cuniculus). The use of model organisms is beneficial to the advances in muscle degeneration research since they are inexpensive, low maintenance, and can be used for genetic screenings. This review illuminated an understanding of the potential application of well-established model organisms in advancing the current knowledge about pathogen-associated muscle degeneration.

Keywords

• animal models
• mus musculus
• oryctolagus cuniculus
• pathogen-associated muscle degeneration
• rattus sp.