Archives of Biological Sciences (Jan 2014)

Non-susceptibility trends among methicillin-resistant coagulase-negative staphylococci isolated from blood cultures

  • Považan Anika,
  • Vukelić Anka,
  • Kurucin Tatjana,
  • Hadnađev Mirjana,
  • Milošević Vesna,
  • Gusman Vera

DOI
https://doi.org/10.2298/ABS1401079P
Journal volume & issue
Vol. 66, no. 1
pp. 79 – 86

Abstract

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Coagulase-negative staphylococci are a significant cause of hospital-acquired bacteremias. There is an increase of infections induced by methicillin-resistant strains, with growing resistance to other antibiotics. The aim of the study was to analyze the resistance of methicillin-resistant coagulase-negative staphylococci isolated from hemocultures in a five-year period. The study was carried out in the microbiology laboratory of the Institute for Pulmonary Diseases of Vojvodina, from 2008 to 2013. Coagulase-negative staphylococci were isolated from 196 hemocultures. Susceptibility tests were performed using the disc diffusion method. Of 196 coagulase-negative staphylococci, 122 (62.2%) were resistant to methicillin, of which 112 (91.8%), 105 (86.1%), 103 (84.4%), 88 (72.1%) were resistant to erythromycin, gentamicin, ciprofloxacin and clindamycin, respectively. All strains were susceptible to vancomycin and linezolid. Multiple resistance was registered in 100 (82%) strains. The most common resistance pattern was gentamicin-erythromycin-clindamycinciprofloxacin. Multiple resistance was established in a significant percentage of methicillin-resistant strains.

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