Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome

Richard S. Beard; Xiaoyuan Yang; Jamie E. Meegan; Jonathan W. Overstreet; Clement G.Y. Yang; John A. Elliott; Jason J. Reynolds; Byeong J. Cha; Christopher D. Pivetti; David A. Mitchell; Mack H. Wu; Robert J. Deschenes; Sarah Y. Yuan

doi:10.1038/ncomms12823

Nature Communications (Sep 2016)

Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome

Richard S. Beard,
Xiaoyuan Yang,
Jamie E. Meegan,
Jonathan W. Overstreet,
Clement G.Y. Yang,
John A. Elliott,
Jason J. Reynolds,
Byeong J. Cha,
Christopher D. Pivetti,
David A. Mitchell,
Mack H. Wu,
Robert J. Deschenes,
Sarah Y. Yuan

Affiliations

Richard S. Beard: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
Xiaoyuan Yang: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
Jamie E. Meegan: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
Jonathan W. Overstreet: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
Clement G.Y. Yang: Department of Surgery, Morsani College of Medicine, University of South Florida
John A. Elliott: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
Jason J. Reynolds: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
Byeong J. Cha: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
Christopher D. Pivetti: Department of Surgery, School of Medicine, University of California at Davis
David A. Mitchell: Department of Molecular Medicine, Morsani College of Medicine, University of South Florida
Mack H. Wu: Department of Surgery, Morsani College of Medicine, University of South Florida
Robert J. Deschenes: Department of Molecular Medicine, Morsani College of Medicine, University of South Florida
Sarah Y. Yuan: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida

DOI: https://doi.org/10.1038/ncomms12823
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 19

Abstract

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Breaking down the endothelial barrier is a hallmark of systemic inflammatory response syndrome. Here the authors show that palmitoylation, a post-translational modification of proteins, plays a critical role in altering endothelial function during inflammation, and suggest the targeting of palmitoyl acyltransferase DHHC21 as potential disease therapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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