Influence of microenvironment on cell adhesion, polarization, and migration

Abstract

Ivana Pajic-Lijakovic, Milenko PlavsicFaculty of Technology and Metallurgy, University of Belgrade, Belgrade, SerbiaWe read an interesting article by Torres-Costa et al1 recently published in the International Journal of Nanomedicine. The influence of the rheological behavior of extracellular matrix (ECM) to cell adhesion and migration represents an important issue for various biomedical applications. The nature of cell adhesion and migration are stochastic as reported by Stokes et al.2 Cell migration should be considered in subcellular and cellular levels by applying fluctuation-dissipation theorem in the form of Langevin-type force-balance equations,3–5 and supercellular level by formulating mesoscopic mass and stress-balance equations.6View the original article by Torres-Costa and colleagues.