Nature Communications (Aug 2018)
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
- Jennifer M. Peterson,
- David J. Wang,
- Vikram Shettigar,
- Steve R. Roof,
- Benjamin D. Canan,
- Nadine Bakkar,
- Jonathan Shintaku,
- Jin-Mo Gu,
- Sean C. Little,
- Nivedita M. Ratnam,
- Priya Londhe,
- Leina Lu,
- Christopher E. Gaw,
- Jennifer M. Petrosino,
- Sandya Liyanarachchi,
- Huating Wang,
- Paul M. L. Janssen,
- Jonathan P. Davis,
- Mark T. Ziolo,
- Sudarshana M. Sharma,
- Denis C. Guttridge
Affiliations
- Jennifer M. Peterson
- Department of Cancer Biology and Genetics
- David J. Wang
- Department of Cancer Biology and Genetics
- Vikram Shettigar
- Center for Muscle Health and Neuromuscular Disorders
- Steve R. Roof
- Center for Muscle Health and Neuromuscular Disorders
- Benjamin D. Canan
- Center for Muscle Health and Neuromuscular Disorders
- Nadine Bakkar
- Department of Cancer Biology and Genetics
- Jonathan Shintaku
- Department of Cancer Biology and Genetics
- Jin-Mo Gu
- Department of Cancer Biology and Genetics
- Sean C. Little
- Center for Muscle Health and Neuromuscular Disorders
- Nivedita M. Ratnam
- Department of Cancer Biology and Genetics
- Priya Londhe
- Department of Cancer Biology and Genetics
- Leina Lu
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
- Christopher E. Gaw
- The Ohio State University Medical Center
- Jennifer M. Petrosino
- Center for Muscle Health and Neuromuscular Disorders
- Sandya Liyanarachchi
- Department of Cancer Biology and Genetics
- Huating Wang
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
- Paul M. L. Janssen
- Center for Muscle Health and Neuromuscular Disorders
- Jonathan P. Davis
- Center for Muscle Health and Neuromuscular Disorders
- Mark T. Ziolo
- Center for Muscle Health and Neuromuscular Disorders
- Sudarshana M. Sharma
- Department of Biochemistry and Molecular Biology, Medical University of South Carolina
- Denis C. Guttridge
- Department of Cancer Biology and Genetics
- DOI
- https://doi.org/10.1038/s41467-018-05910-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expression.
