Nature Communications (Aug 2019)
Wilm’s tumor 1 promotes memory flexibility
- Chiara Mariottini,
- Leonardo Munari,
- Ellen Gunzel,
- Joseph M. Seco,
- Nikos Tzavaras,
- Jens Hansen,
- Sarah A. Stern,
- Virginia Gao,
- Hossein Aleyasin,
- Ali Sharma,
- Evren U. Azeloglu,
- Georgia E. Hodes,
- Scott J. Russo,
- Vicki Huff,
- Marc R. Birtwistle,
- Robert D. Blitzer,
- Cristina M. Alberini,
- Ravi Iyengar
Affiliations
- Chiara Mariottini
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Leonardo Munari
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Ellen Gunzel
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Joseph M. Seco
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Nikos Tzavaras
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Jens Hansen
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Sarah A. Stern
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Virginia Gao
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Hossein Aleyasin
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Ali Sharma
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Evren U. Azeloglu
- Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai
- Georgia E. Hodes
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Scott J. Russo
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Vicki Huff
- Department of Genetics, M.D. Anderson Cancer Center, University of Texas
- Marc R. Birtwistle
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Robert D. Blitzer
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Cristina M. Alberini
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Ravi Iyengar
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-019-11781-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.
