Breast Cancer: Targets and Therapy (Jul 2023)
On Ultrasonographic Features of Mucinous Carcinoma with Micropapillary Pattern
Abstract
Wei-Sen Yang,1,* Yang Li,2,* Ya Gao3 1Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Radiology, Wuxi No.2 People’s Hospital, Wuxi, People’s Republic of China; 3Center for Medical Ultrasound, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ya Gao, Center for Medical Ultrasound, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, No. 16 of West Baita Road, Gusu District, Suzhou, 215001, People’s Republic of China, Tel +86-51262364301, Fax +86-51262362596, Email [email protected]: To describe the sonographic features of pure mucinous carcinoma with micropapillary pattern (MUMPC) and compare with different pathological type of mucinous breast carcinoma.Methods: Subjects were retrospectively reviewed at Suzhou Municipal Hospital from January 2015 to June 2019. Sonographic features of 49 cases (9 MUMPC, 19cPMBC, and 21 MMBC) pathologically confirmed MBC were recorded according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon. The differences in sonographic features among different type of mucinous breast carcinoma were discussed, including clinical features and sonographic features, shape, lesion boundary, peripheral hyperechoic ring, echo pattern, posterior acoustic feature, thickness peripheral hyperechoic area, and blood flow.Results: All MUMPC had no lymph node metastasis (88.9%, 8/9), and most of the MUMPC showed no thickness peripheral hyperechoic area (88.9%, 8/9) and blood flow (55.6%, 5/9) within the tumor. Furthermore, MUMPC had mixed cystic and solid components (33.3%, 3/9) and solid echoic (66.7%, 6/9) structures, with regular shape (66.7%, 6/9) and peripheral hyperechoic ring (66.7%, 6/9). Seven cases of the MUMPC showed circumscribed margin (77.8%, 7/9), and there was significant difference among the three groups (p 0.05).Conclusion: Most of the MUMPC showed a circumscribed margin, peripheral hyperechoic ring, and without lymph node metastasis and thickness peripheral hyperechoic area. However, it is challenging to distinguish MUMPC from PMBC and MMBC on ultrasound. Future research should focus on developing novel analysis methods for ultrasound imaging, conducting studies with larger sample sizes and diverse population groups.Keywords: breast, pure mucinous carcinoma, micropapillary, mixed mucinous carcinoma, ultrasonography
