Infection and Drug Resistance (Jun 2021)
Role of Bacteria in the Incidence of Common GIT Cancers: The Dialectical Role of Integrated Bacterial DNA in Human Carcinogenesis
Abstract
Sayed K Elagan,1 Saad J Almalki,1 MR Alharthi,1 Mohamed S Mohamed,1 Mohamed F EL-Badawy2 1Department of Mathematics and Statistics, College of Science, Taif University, Taif, 21944, Saudi Arabia; 2Department of Microbiology and Immunology, Faculty of Pharmacy, University of Sadat City, Sadat City, 32958, EgyptCorrespondence: Mohamed F EL-BadawyDepartment of Microbiology and Immunology, Faculty of Pharmacy, University of Sadat City, Menoufia Governorate, Sadat City, 32958, EgyptTel +20-103-205-9964Email [email protected]: Despite the wide medical knowledge about the direct role of many viruses in the pathogenesis of certain cancers, there is still ambiguity and hazy vision about the direct role of bacteria in cancer incidence. Understanding the role of bacteria in carcinogenesis is no longer a scientific luxury, but it has become an urgent and extremely important necessity to realize the pathogenesis of cancer caused by oncogenic bacteria as an attempt to overcome the oncogenic mechanisms exhibited by these oncogenic bacteria. This review shed the light on the indirect role of the host’s inflammatory and immunological responses in the pathogenesis of bacteria-induced cancer. Also, this review discussed the indirect role of the bacterial toxins and virulence factors in the induction of common gastrointestinal cancers, such as gallbladder cancer (GBC), colorectal cancer (CRC), and gastric cancer (GC). Finally, this review dealt with the debate about the possibility of bacterial DNA integration into the human genome and cancer incidence.Keywords: cancer, oncogenic bacteria, DNA, genome, gall bladder cancer
