Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism

Michael Landowski; Vijesh J. Bhute; Samuel Grindel; Zachary Haugstad; Yeboah K. Gyening; Madison Tytanic; Richard S. Brush; Lucas J. Moyer; David W. Nelson; Christopher R. Davis; Chi-Liang Eric Yen; Sakae Ikeda; Martin-Paul Agbaga; Akihiro Ikeda

doi:10.1038/s42003-022-04404-7

Communications Biology (Jan 2023)

Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism

Michael Landowski,
Vijesh J. Bhute,
Samuel Grindel,
Zachary Haugstad,
Yeboah K. Gyening,
Madison Tytanic,
Richard S. Brush,
Lucas J. Moyer,
David W. Nelson,
Christopher R. Davis,
Chi-Liang Eric Yen,
Sakae Ikeda,
Martin-Paul Agbaga,
Akihiro Ikeda

Affiliations

Michael Landowski: Department of Medical Genetics, University of Wisconsin-Madison
Vijesh J. Bhute: Department of Medical Genetics, University of Wisconsin-Madison
Samuel Grindel: Department of Medical Genetics, University of Wisconsin-Madison
Zachary Haugstad: Department of Medical Genetics, University of Wisconsin-Madison
Yeboah K. Gyening: Department of Cell Biology, University of Oklahoma Health Sciences Center
Madison Tytanic: Department of Ophthalmology, University of Oklahoma Health Sciences Center
Richard S. Brush: Department of Ophthalmology, University of Oklahoma Health Sciences Center
Lucas J. Moyer: Department of Medical Genetics, University of Wisconsin-Madison
David W. Nelson: Department of Nutritional Sciences, University of Wisconsin-Madison
Christopher R. Davis: Department of Nutritional Sciences, University of Wisconsin-Madison
Chi-Liang Eric Yen: Department of Nutritional Sciences, University of Wisconsin-Madison
Sakae Ikeda: Department of Medical Genetics, University of Wisconsin-Madison
Martin-Paul Agbaga: Department of Cell Biology, University of Oklahoma Health Sciences Center
Akihiro Ikeda: Department of Medical Genetics, University of Wisconsin-Madison

DOI: https://doi.org/10.1038/s42003-022-04404-7
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 15

Abstract

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Lipid analysis of transmembrane protein 135 (TMEM135) mutant mice reveals robust decreases in docosahexaenoic acid (DHA), indicating a function of TMEM135 on the export of DHA from peroxisomes that is important for maintaining lipid metabolism.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal