Modern tendency of prevention and treatment of infectious processes of the lower genital tract

Abstract

Issue of the treatment of mixed genital infections and prevention of reproductive health disorders caused by them has not lost medical and social significance, which is associated with a high frequency of mixed infections, absence of pathognomonic clinical manifestations, and with a constantly significant frequency of sexually transmitted infections (chlamydia, genital herpes, trichomoniasis, etc.). It should be controlled and rationally limited antibiotics use in connection with a sharp increase in microorganisms’ resistance. At the same time proven antiseptics which are used to reduce the infection risk or to treat vaginal infections do not contribute to the formation of resistant pathogens. The purpose of this literature review was to analyze publications about modern antiseptic octenidine dihydrochloride for mucous membranes, skin and wounds and the prospects for it use in obstetric and gynecological practice. Octenidine dihydrochloride (octenidine) was synthesized as a multi-functional antiseptic for skin, mucous membranes and wounds. Today octenidine is an active antiseptic with a wide scope of use and is an alternative to chlorhexidine, povidone iodine, triclosan, etc. Octenidine is a cationic antiseptic of a new chemical group (derivatives of bispyridinamine), is a safe and effective antimicrobial agent with a high level and spectrum of antimicrobial activity. The antiseptic activity of octenidine is achieved within 30 seconds, it is chemically resistant, has proven low toxicity to humans and the environment and high clinical efficacy, does not cause the pathogen resistance, is approved for use from the second trimester in pregnancy and during breastfeeding. Octenidine use with or without combinations should be considered as an integral part of the standard therapy for various types of vaginitis and bacterial vaginosis. Octenidine can become a promising agent for therapeutic indications in gynecology in future, since it surpasses povidone iodine, polyhexanide and chlorhexidine in the efficiency of microorganisms’ eradication from the mucous membranes.

Keywords

• antiseptic
• bacterial vaginosis
• vaginitis
• octenidine dihydrochloride
• prophylaxis
• prodexin