Crosslinked nanocollagen-cellulose nanofibrils reinforced electrospun polyvinyl alcohol/methylcellulose/polyethylene glycol bionanocomposites: Study of material properties and sustained release of ketorolac tromethamine

Abstract

Engaged potent drug delivery systems (DDSs) has greatly influence on managing the drug pharmacological outcome and the pharmacokinetic outline with regards to the drug release rate, the target site, drug bioavailability without neglecting the side effects. The endeavor of this work is to investigate the effect of reinforcing nanofillers on drug release, and other properties of the nanofiller-drug loaded nanofibrous systems. In this research work, cellulose nanofibrils (CNF) has been isolated from jute fibres while nanocollagen (NCG) was extracted from waste fish scales for the fabrication of CNF-NCG reinforced drug loaded PVA/MC/PEG glutaraldehyde cross-linked novel electrospun nanofibrous bionanocomposites (BNCs). The prepared BNCs were characterized by Fourier Transform Infrared (FTIR) Spectroscopy and Field emission scanning electron microscopy (FESEM). In vitro drug release results showed that the CNF-NCG BNCs loaded nanofibrous structures displayed excellent sustained release of KT up to ≥16 h and can serve as excellent transdermal DDSs.

Keywords

• Cellulose nanofibrils
• Composite electrospinning
• Drug delivery
• Jute
• Nanocollagen
• Polyvinyl alcohol