Investigation of Antiviral Activity of Adamantan Boron Derivaties on Pandemic Influenza Virus Models

Abstract

Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. The minimum inhibitory concentration (MIC) of the products was 0.1 mcg/ml. The use of liposomes loaded with BG 12 molecules in the optimal concentration (0.1 mcg/ml) resulted in inhibition of the avian plague virus growth in the MDCK cells. Possible design of efficient drugs for antiviral protection based on the complexes liposomes - boron-containing compounds is discussed.

Keywords

• 1-бораадамантан
• 1-boronadamantan
• boron-containing compounds
• pandemic avian and swine influenza viruses
• liposomes