Dedifferentiated Melanoma: A Diagnostic Histological Pitfall—Review of the Literature with Case Presentation

Gerardo Cazzato; Lucia Lospalluti; Anna Colagrande; Antonietta Cimmino; Paolo Romita; Caterina Foti; Aurora Demarco; Francesca Arezzo; Vera Loizzi; Gennaro Cormio; Sara Sablone; Leonardo Resta; Roberta Rossi; Giuseppe Ingravallo

doi:10.3390/dermatopathology8040051

Dermatopathology (Oct 2021)

Dedifferentiated Melanoma: A Diagnostic Histological Pitfall—Review of the Literature with Case Presentation

Gerardo Cazzato,
Lucia Lospalluti,
Anna Colagrande,
Antonietta Cimmino,
Paolo Romita,
Caterina Foti,
Aurora Demarco,
Francesca Arezzo,
Vera Loizzi,
Gennaro Cormio,
Sara Sablone,
Leonardo Resta,
Roberta Rossi,
Giuseppe Ingravallo

Affiliations

Gerardo Cazzato: Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Lucia Lospalluti: Section of Dermatology, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Anna Colagrande: Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Antonietta Cimmino: Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Paolo Romita: Section of Dermatology, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Caterina Foti: Section of Dermatology, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Aurora Demarco: Section of Dermatology, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Francesca Arezzo: Section of Ginecology and Obstetrics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Vera Loizzi: Section of Ginecology and Obstetrics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Gennaro Cormio: Section of Ginecology and Obstetrics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Sara Sablone: Section of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124 Bari, Italy
Leonardo Resta: Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Roberta Rossi: Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy
Giuseppe Ingravallo: Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy

DOI: https://doi.org/10.3390/dermatopathology8040051
Journal volume & issue: Vol. 8, no. 4
pp. 494 – 501

Abstract

Read online

Dedifferentiated melanoma is a particular form of malignant melanoma with a progressive worsening of the patient’s clinical outcome. It is well known that melanoma can assume different histo-morphological patterns, to which specific genetic signatures correspond, sometimes but not always. In this review we address the diagnostic difficulties in correctly recognizing this entity, discuss the major differential diagnoses of interest to the dermatopathologist, and conduct a review of the literature with particular attention and emphasis on the latest molecular discoveries regarding the dedifferentiation/undifferentiation mechanism and more advanced therapeutic approaches.

Published in Dermatopathology

ISSN: 2296-3529 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Dermatology
Website: https://www.mdpi.com/journal/dermatopathology

About the journal

Abstract

Keywords