Scientific Reports (Jul 2022)
Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China
- Chun-Hong Jia,
- Zhou-Shan Feng,
- Xiao-Jun Lin,
- Qi-Liang Cui,
- Sha-Sha Han,
- Ya Jin,
- Guo-Sheng Liu,
- Chuan-Zhong Yang,
- Xiao-Tong Ye,
- Yi-Heng Dai,
- Wei-Yi Liang,
- Xiu-Zhen Ye,
- Jing Mo,
- Lu Ding,
- Ben-Qing Wu,
- Hong-Xiang Chen,
- Chi-Wang Li,
- Zhe Zhang,
- Xiao Rong,
- Wei-Min Huang,
- Wei Shen,
- Bing-Yan Yang,
- Jun-Feng Lv,
- Le-Ying Huo,
- Hui-Wen Huang,
- Hong-Ping Rao,
- Wen-Kang Yan,
- Yong Yang,
- Xue-Jun Ren,
- Dong Liu,
- Fang-Fang Wang,
- Shi-Guang Diao,
- Xiao-Yan Liu,
- Chu-Ming You,
- Qiong Meng,
- Bin Wang,
- Li-Juan Zhang,
- Yu-Ge Huang,
- Dang Ao,
- Wei-Zhong Li,
- Jie-Ling Chen,
- Yan-Ling Chen,
- Wei Li,
- Zhi-Feng Chen,
- Yue-Qin Ding,
- Xiao-Yu Li,
- Yue-Fang Huang,
- Ni-Yang Lin,
- Yang-Fan Cai,
- Zhong-He Wan,
- Yi Ban,
- Bo Bai,
- Guang-Hong Li,
- Yue-Xiu Yan,
- Fan Wu
Affiliations
- Chun-Hong Jia
- Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University
- Zhou-Shan Feng
- Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University
- Xiao-Jun Lin
- Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University
- Qi-Liang Cui
- Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University
- Sha-Sha Han
- Department of Neonatology, The First Affiliated Hospital of Jinan University
- Ya Jin
- Department of Neonatology, The First Affiliated Hospital of Jinan University
- Guo-Sheng Liu
- Department of Neonatology, The First Affiliated Hospital of Jinan University
- Chuan-Zhong Yang
- Department of Neonatology, Shenzhen Maternal and Child Healthcare Hospital, Affiliated Southern Medical University
- Xiao-Tong Ye
- Department of Neonatology, Shenzhen Maternal and Child Healthcare Hospital, Affiliated Southern Medical University
- Yi-Heng Dai
- Department of Neonatology, Foshan Maternal and Child’s Hospital
- Wei-Yi Liang
- Department of Neonatology, Foshan Maternal and Child’s Hospital
- Xiu-Zhen Ye
- Department of Neonatology, Women and Children Hospital of Guangdong Province
- Jing Mo
- Department of Neonatology, Women and Children Hospital of Guangdong Province
- Lu Ding
- Department of Neonatology, Shenzhen People’s Hospital
- Ben-Qing Wu
- Department of Neonatology, Shenzhen People’s Hospital
- Hong-Xiang Chen
- Department of Neonatology, Meizhou People’s Hospital
- Chi-Wang Li
- Department of Neonatology, Meizhou People’s Hospital
- Zhe Zhang
- Department of Neonatology, Guangzhou Women and Children’s Medical Center
- Xiao Rong
- Department of Neonatology, Guangzhou Women and Children’s Medical Center
- Wei-Min Huang
- Department of Neonatology, Nanfang Hospital of Southern Medical University
- Wei Shen
- Department of Neonatology, Nanfang Hospital of Southern Medical University
- Bing-Yan Yang
- Department of Neonatology, Boai Hospital of Zhongshan
- Jun-Feng Lv
- Department of Neonatology, Boai Hospital of Zhongshan
- Le-Ying Huo
- Department of Neonatology, Zhuhai Maternity and Child Health Hospital
- Hui-Wen Huang
- Department of Neonatology, Zhuhai Maternity and Child Health Hospital
- Hong-Ping Rao
- Department of Neonatology, Huizhou Municipal Central Hospital
- Wen-Kang Yan
- Department of Neonatology, Huizhou Municipal Central Hospital
- Yong Yang
- Department of Neonatology, Dongguan Maternity and Child Health Hospital
- Xue-Jun Ren
- Department of Neonatology, Dongguan Maternity and Child Health Hospital
- Dong Liu
- Department of Neonatology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University
- Fang-Fang Wang
- Department of Neonatology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University
- Shi-Guang Diao
- Department of Neonatology, Yuebei People’s Hospital
- Xiao-Yan Liu
- Department of Neonatology, Yuebei People’s Hospital
- Chu-Ming You
- Department of Neonatology, Guangdong Second Provincial People’s Hospital
- Qiong Meng
- Department of Neonatology, Guangdong Second Provincial People’s Hospital
- Bin Wang
- Department of Pediatrics, Zhujiang Hospital of Southern Medical University
- Li-Juan Zhang
- Department of Pediatrics, Zhujiang Hospital of Southern Medical University
- Yu-Ge Huang
- Department of Pediatrics, The Affiliated Hospital of Guangdong Medical University
- Dang Ao
- Department of Pediatrics, The Affiliated Hospital of Guangdong Medical University
- Wei-Zhong Li
- Department of Neonatology, The Second Affiliated Hospital of Shantou University Medical College
- Jie-Ling Chen
- Department of Neonatology, The Second Affiliated Hospital of Shantou University Medical College
- Yan-Ling Chen
- Department of Neonatology, Jinan University Medical College Affiliated Dongguan Hospital
- Wei Li
- Department of Neonatology, Jinan University Medical College Affiliated Dongguan Hospital
- Zhi-Feng Chen
- Department of Pediatrics, Dongguan People’s Hospital
- Yue-Qin Ding
- Department of Pediatrics, Dongguan People’s Hospital
- Xiao-Yu Li
- Department of Neonatology, The First Affiliated Hospital of Sun Yat-Sen University
- Yue-Fang Huang
- Department of Neonatology, The First Affiliated Hospital of Sun Yat-Sen University
- Ni-Yang Lin
- Department of Neonatology, The First Affiliated Hospital of Shantou University Medical College
- Yang-Fan Cai
- Department of Neonatology, The First Affiliated Hospital of Shantou University Medical College
- Zhong-He Wan
- Department of Neonatology, Nanhai District People’s Hospital of Foshan
- Yi Ban
- Department of Neonatology, Nanhai District People’s Hospital of Foshan
- Bo Bai
- Department of Neonatology, Huadu District People’s Hospital of Guangzhou
- Guang-Hong Li
- Department of Neonatology, Huadu District People’s Hospital of Guangzhou
- Yue-Xiu Yan
- Department of Pediatrics, The First People’s Hospital of Zhaoqing
- Fan Wu
- Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University
- DOI
- https://doi.org/10.1038/s41598-022-14432-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Abstract With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged from twenty-six neonatal intensive care units in Guangdong Province of China during 2008–2017 were analyzed. A total of 2575 ELBW infants were enrolled and the overall survival rate was 55.11%. From 2008 to 2017, the number of ELBW infants increased rapidly from 91 to 466, and the survival rate improved steadily from 41.76% to 62.02%. Increased survival is closely related to birth weight (BW), regional economic development, and specialized hospital. The incidence of complications was neonatal respiratory distress syndrome (85.2%), oxygen dependency at 28 days (63.7%), retinopathy of prematurity (39.3%), intraventricular hemorrhage (29.4%), necrotizing enterocolitis (12.0%), and periventricular leukomalacia (8.0%). Among the 1156 nonsurvivors, 90.0% of infants died during the neonatal period (≤ 28 days). A total of 768 ELBW infants died after treatment withdrawal, for reasons of economic and/or poor outcome. The number of ELBW infants is increasing in Guangdong Province of China, and the overall survival rate is improving steadily.
