The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells

Takeshi Ito; Yohei Kawai; Yutaka Yasui; Shoichi Iriguchi; Atsutaka Minagawa; Tomoko Ishii; Hiroyuki Miyoshi; M. Mark Taketo; Kenji Kawada; Kazutaka Obama; Yoshiharu Sakai; Shin Kaneko

doi:10.1038/s42003-021-02195-x

Communications Biology (Jun 2021)

The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells

Takeshi Ito,
Yohei Kawai,
Yutaka Yasui,
Shoichi Iriguchi,
Atsutaka Minagawa,
Tomoko Ishii,
Hiroyuki Miyoshi,
M. Mark Taketo,
Kenji Kawada,
Kazutaka Obama,
Yoshiharu Sakai,
Shin Kaneko

Affiliations

Takeshi Ito: Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Shogoin-Kawahara-cho
Yohei Kawai: Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Shogoin-Kawahara-cho
Yutaka Yasui: Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Shogoin-Kawahara-cho
Shoichi Iriguchi: Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Shogoin-Kawahara-cho
Atsutaka Minagawa: Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Shogoin-Kawahara-cho
Tomoko Ishii: Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Shogoin-Kawahara-cho
Hiroyuki Miyoshi: Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University, Yoshida-Honmachi
M. Mark Taketo: Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University, Yoshida-Honmachi
Kenji Kawada: Department of Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho
Kazutaka Obama: Department of Surgery, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho
Yoshiharu Sakai: Osaka Red Cross Hospital, Fudegasaki-cho
Shin Kaneko: Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Shogoin-Kawahara-cho

DOI: https://doi.org/10.1038/s42003-021-02195-x
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 16

Abstract

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Ito et al. generated and characterized multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-derived iPS cells (TIL-iPSC) using human colorectal cancer specimens. They demonstrated that the newly-generated T cells retained intrinsic characters and acquired improved functions with less differentiated profiles, thus constituting a potential therapeutic anti-cancer tool.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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